Splice is a 2009 Canadian-French science fiction-horror film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray a young scientist couple, choosing to introduce human DNA into their work of splicing animal genes.
Though they disagree about actually bringing the hybrid to term, Elsa pushes the issue and she persuades Clive to go along with it, in continued secrecy. They name their creature Dren (nerd backwards), who exceeds their wildest dreams; she begins to grow and learn at an accelerated rate. As their lab becomes exceedingly crowded, and the risk of Dren being discovered increases, they move Dren to Elsa's late mother's farm.
Their work at the company suffers as their attention is focused on Dren. One of the original hybrid animals that they had created, which was originally female, had changed sex unbeknownst to Clive & Elsa since they were distracted. This led to a disastrous presentation during a company shareholders' meeting, when the two original hybrids, previously one male and one female very much in love with each other, became both male, killed each other in front of shareholders and potential investors. Following this meeting, N.E.R.D., found itself in danger of going out of business unless they could find a profitable discovery.
Meanwhile, Dren has become amphibious and omnivorous with a toxic sting and retractable wings coming out of parts of her arm and back. Elsa, who had formed a maternal bond with Dren, changes her mind after Dren shows violent behavior, killing her own pet cat out of spite and assaulting her. She cuts off her stinger and uses organic tissue from it to finally isolate and synthesize a protein they had been searching for.
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Official Site: Warner Bros.
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