Abominatrix is a fictional human mutate supervillain in the Marvel Universe. The character first appeared in Sensational She-Hulk #21 (November 1990).

Florence Sharples worked for Jasper Keaton, manager of a saving and loan company.

Keaton sponsored genetic research, seeking a cure for pre-menstrual syndrome.

Sharples was transformed into the Abominatrix as an accidental effect of the "cure".

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