Madame Rouge is a fictional DC Comics supervillainess. She first appeared in Doom Patrol v.1 #86.
Laura De Mille was originally a French stage actress. After an automobile accident, she developed a dual good/evil split personality. At this point, she attracted the notice of The Brain and his associate, Monsieur Mallah. With Mallah's help, the Brain performed surgery on De Mille that was, from his perspective, successful, sublimating her good personality and allowing her evil personality to remain dominant. As Madame Rouge, De Mille became the only female member of the Brotherhood of Evil, and assisted the Brotherhood in its continuing conflicts against the Doom Patrol. At first, Madame Rouge was simply a master of disguise; subsequent surgery by the Brain eventually gave her the ability to alter her appearance and stretch her limbs.
Later, Rouge's split personality manifested again, with her good personality occasionally appearing. Rouge was romantically linked to the Doom Patrol's leader, Niles Caulder ("The Chief"), who was able to help Rouge overcome her evil side and ally with the Doom Patrol.
Ultimately, Rouge's mind reverted back to its evil state, causing her to seek vengeance against both the Brotherhood of Evil and the Doom Patrol for their previous interference. She was apparently successful in murdering both groups. Years later, Robotman and the Teen Titans tracked down Rouge and her ally, General Zahl. Beast Boy (then Changeling) killed Rouge, although at the moment of her death, her good side apparently manifested; she forgave Changeling and called to Niles, her apparent true love.
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Official Site: D.C Comics
Links: Wikipedia Michael Kooiman web page Titans Tower