The OMACs (Omni Mind And Community, originally Observational Metahuman Activity Construct) are a fictional type of powerful cyborg that exist in the DC Comics universe. Based on the Jack Kirby character of the same name, the OMACs were created by Greg Rucka and first appeared in The OMAC Project #1 (June 2005).
The OMACs are cyborgs who take over human bodies via a virus in order to assassinate any and all beings with superpowers. The virus was created from Brainiac-13-derived nanotechnology acquired by the U.S. Department of Defense and Lexcorp, which was then secretly introduced into general vaccine supplies. The OMACs are featured in the mini-series The OMAC Project that leads up to the Infinite Crisis series.
The new OMACs are controlled by the Brother MK I satellite. Brother MK I was created by Batman and programmed by Pseudopersons, Inc. scientist Buddy Blank, who in this retelling of the story is a consociate of Wayne Industries. Its purpose was to keep an eye on all metahuman, both villain and hero, after Batman grew distrustful over the Justice League's mindwiping (see Identity Crisis). Alexander Luthor, Jr. later gave the satellite sentience as part of his plans. Maxwell Lord subverted the original mission of the Brother MK I satellite by inculcating a fear and suspicion of all metahumans when he rose to the top rank of the government agency Checkmate. Ironically enough, the first test subject activated shared his name with his "father" and his alternate version, both being called Buddy Blank.
However, the OMACs' history may be more recent than Brother MK I's itself. Equus and Pilates, formerly featured in Superman: For Tomorrow, are later denounced as supposed former iterations of the OMAC concept; and in JLA: Classified an all mechanic OMAC is featured as an enemy for the Metal Men. Since then, the design has improved to the current form, with little to no changes to the base model, aside from Sasha Bordeaux.
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Official Site: DC Comics
Links: OMAC Project Wiki DCUGuide entry Reference.com page